Thursday, April 19, 2012

Pubmed April 2012 Update

Here we go with April 2012 ...

Rosca P, Haklai Z, Goldberger N, Zohar P, Margolis A, Ponizovsky AM.
Drug Alcohol Depend. 2012 Apr 6. [Epub ahead of print]
Comment: Rate of overdose mortality was 0.22/100 person-years (i.e. 0.22%), one-quarter to one-fifth the expected rate in most studies of other cohorts

Yokell MA, Zaller ND, Green TC, McKenzie M, Rich JD.
J Opioid Manag. 2012 Jan-Feb;8(1):63-6.
Comment: Buprenorphine is a partial agonist with a ceiling effect that limits the capacity for overdose among those with a tolerance to opioids. Like naloxone, buprenorphine really likes binding to opioid receptors and kicks most other opioids out. Since buprenorphine out-competes other opioids for receptors and has a ceiling effect, administration in the setting of overdose may result in reversal of opioid overdose. That said, this wouldn't be the approach I would advocate for dissemination since (1) buprenorphine could cause overdose in an opioid user with minimal tolerance and (2) buprenorphine could cause prolonged withdrawal (for over a day) in those with a very high tolerance.

Andrews JY, Kinner SA.
BMC Public Health. 2012 Apr 4;12(1):270. [Epub ahead of print]
Comment: An interesting exploration of circumstances surrounding prisoner death post-release.

Goli V, Webster LR, Lamson MJ, Cleveland JM, Sommerville KW, Carter E.
Harm Reduct J. 2012 Mar 15;9(1):13. [Epub ahead of print]
Comment: An intriguing analysis of whether or not injecting the pre-formulated morphine + naltrexone actually blocks the effects of morphine. It appears to partially, but not completely, block the effect.

Kinner SA, Milloy MJ, Wood E, Qi J, Zhang R, Kerr T.
Addict Behav. 2012 Feb 7. [Epub ahead of print]
Comment: Prior overdose, daily or binge drug use, and public injecting are associated with nonfatal overdose among recently released drug users.

Upadhyay SP, Mallick PN, Elmatite WM, Jagia M, Taqi S.
Indian J Palliat Care. 2011 Sep;17(3):251-4.
Comment: An interesting use of a particular sedative to assist with opioid withdrawal in an intensive care unit.

Wilcher G.
Am J Forensic Med Pathol. 2011 Dec;32(4):314-8.
Comment: Intriguing review of 5 cases of drug-induced death among "body packers" or "body stuffers", including a review of that language. Interestingly, most of the deaths were due to overdose on consumed drugs rather than toxicity from rupture of drug packets.


  1. Phillip - Thanks again for keeping your keen eye on the lit and translating it for us lay -- read 'too lazy' --folk... Peace, Dan

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